Synthetic Route of 152460-09-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 152460-09-8, name is N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine. A new synthetic method of this compound is introduced below.
General procedure: A mixture of the organic nitro compound (1.0 mmol), NH2NH2¡¤H2O (2.5 equiv.) and H2O2-treated AC powder (50 wt%) in DMF (1.5 mL) was stirred vigorously magnetically at 100 C. The reaction was monitored by LC-MS or GC-MS. On completion the reaction mixture was filtered to remove the catalyst. The combined organic mixture material was dried using anhydrous Na2SO4 and filtered. The solvent was removed under reduced pressure to obtain the products. All the compounds were known and characterised by their 1H NMR and MS spectra and comparison with literature data.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,152460-09-8, its application will become more common.
Reference:
Article; Jiang, Yuqin; Suo, Huajun; Zhang, Dandan; Li, Xiyong; Sun, Yamin; Ren, Baoqi; Zhang, Weiwei; Xu, Guiqing; Journal of Chemical Research; vol. 41; 9; (2017); p. 509 – 512;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem