Schaffner, Arnaud-Pierre; Sansilvestri-Morel, Patricia; Despaux, Nicole; Ruano, Elisabeth; Persigand, Thierry; Rupin, Alain; Mennecier, Philippe; Vallez, Marie-Odile; Raimbaud, Eric; Desos, Patrice; Gloanec, Philippe published an article in 2021. The article was titled 《Phosphinanes and Azaphosphinanes as Potent and Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa)》, and you may find the article in Journal of Medicinal Chemistry.Category: pyridine-derivatives The information in the text is summarized as follows:
Selective and potent inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa) have the potential to increase endogenous and therapeutic fibrinolysis and to behave like profibrinolytic agents without the risk of major hemorrhage, since they do not interfere either with platelet activation or with coagulation during blood hemostasis. Therefore, TAFIa inhibitors could be used in at-risk patients for the treatment, prevention, and secondary prevention of stroke, venous thrombosis, and pulmonary embolisms. In this paper, we describe the design, the structure-activity relationship (SAR), and the synthesis of novel, potent, and selective phosphinanes and azaphosphinanes as TAFIa inhibitors. Several highly active azaphosphinanes display attractive properties suitable for further in vivo efficacy studies in thrombosis models. The experimental process involved the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5Category: pyridine-derivatives)
2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Category: pyridine-derivatives