Recommanded Product: 4-Amino-2-picolineOn March 28, 2019, Rombouts, Frederik J. R.; Declercq, Lieven; Andres, Jose-Ignacio; Bottelbergs, Astrid; Chen, Lu; Iturrino, Laura; Leenaerts, Joseph E.; Marien, Jonas; Song, Fengbin; Wintmolders, Cindy; Wuyts, Stijn; Xia, Chunfang A.; te Riele, Paula; Bormans, Guy; Vandenberghe, Rik; Kolb, Hartmuth; Moechars, Diederik published an article in Journal of Medicinal Chemistry. The article was 《Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer》. The article mentions the following:
In Alzheimer’s disease, the d. and spread of aggregated tau protein track well with neurodegeneration and cognitive decline, making the imaging of aggregated tau a compelling biomarker. A structure-activity relationship exploration around an isoquinoline hit, followed by an exploration of tolerated fluorination positions, allowed us to identify 9 (JNJ-64326067), a potent and selective binder to aggregated tau with a favorable pharmacokinetic profile and no apparent off-target binding. This was confirmed in rat and monkey positron emission tomog. studies using [18F]9. In the part of experimental materials, we found many familiar compounds, such as 4-Amino-2-picoline(cas: 18437-58-6Recommanded Product: 4-Amino-2-picoline)
4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Recommanded Product: 4-Amino-2-picoline