Name: 4-EthynylpyridineIn 2019 ,《Novel SAR for quinazoline inhibitors of EHMT1 and EHMT2》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Leenders, Ruben; Zijlmans, Remco; van Bree, Bart; van de Sande, Marc; Trivarelli, Federica; Damen, Eddy; Wegert, Anita; Mueller, Daniel; Ehlert, Jan Erik; Feger, Daniel; Heidemann-Dinger, Carolin; Kubbutat, Michael; Schaechtele, Christoph; Lenstra, Danny C.; Mecinovic, Jasmin; Mueller, Gerhard. The article conveys some information:
Detailed structure activity relationship of two series of quinazoline EHMT1/EHMT2 inhibitor compounds I [R = COOH, CONH2, (5-prop-2-ynylpyrrolidin-2-one)-3-yl etc.] and II [R1 = OMe, F, OCF3 ; R2 = aminopropynyl,(5-prop-2-ynylpyrrolidin-2-one)-3-yl etc.] were elaborated. New and active alternatives were presented for the ubiquitous substitution patterns found in literature for the linker to the lysine mimicking region and the lysine mimic itself. After reading the article, we found that the author used 4-Ethynylpyridine(cas: 2510-22-7Name: 4-Ethynylpyridine)
4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 4-Ethynylpyridine