Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 626-05-1, name is 2,6-Dibromopyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C5H3Br2N
A mixture of 2,6-dibromopyridine (4.83 g, 20.4 mmol), NaI (4.00 g, 26.7 mmol, 1.3 equiv.), and 57% HI (15 mL, 0.20 mol, 9.8 equiv.) in H2O was stirred at 140 C in a sealed tube suitable for high-pressure reactions (Note 1) for ca. 12 h (Note 2). The resulting yellow slurry was allowed to cool to rt after which the contents of the reaction vessel were poured into crushed ice (re-melted using a heat gun if necessary). Using concentrated aqueous NaOH, the pH was adjusted to neutral and the mixture was extracted with Et2O (3 x 200 mL). The combined organic extracts were washed with saturated aqueous NaHCO3 (50 mL) and saturated aqueous NaS2O3 (50 mL), dried with Na2SO4, filtered, and concentrated in vacuum. Purification using dry column vacuum chromatography (0-10% EtOAc / heptanes, 1% increments, 100 mL fractions) followed by recrystallization from boiling heptanes gave 12 (3.33 g, 20.4 mmol, 49%) as colorless thread thin needles.
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Reference:
Article; Broman, S¡ãren Lindbaek; Andersen, Cecilie Lindholm; Jevric, Martyn; Tortzen, Christian Gregers; Hammerich, Ole; Nielsen, Mogens Br¡ãndsted; Tetrahedron; vol. 72; 39; (2016); p. 5831 – 5842;,
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