In 2019,Organic & Biomolecular Chemistry included an article by Satpathi, Bishnupada; Dutta, Lona; Ramasastry, S. S. V.. Recommanded Product: 2-Bromonicotinaldehyde. The article was titled 《Phosphine- and water-promoted pentannulative aldol reaction》. The information in the text is summarized as follows:
An efficient metal-free intramol. aldol reaction for the synthesis of an unusual class of cyclopentanoids was described. The reaction of α-substituted dienones tethered with ketones in the presence of tributylphosphine and water provided aldols. The role of water was realized to be crucial for this transformation. Furthermore, isotopic labeling experiments provided vital information about the reaction mechanism. In the experiment, the researchers used 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 2-Bromonicotinaldehyde)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 2-Bromonicotinaldehyde