In 2015,Mou, Jianfeng; Park, Ann; Cai, Yu; Yuan, Junying; Yuan, Chengye published 《Structure-activity relationship study of E6 as a novel necroptosis inducer》.Bioorganic & Medicinal Chemistry Letters published the findings.Reference of 6-Bromopyridin-3-amine The information in the text is summarized as follows:
Necroptosis inducers represent a promising potential treatment for drug-resistant cancer. We herein describe the structure modification of E6, which was identified recently as a potent and selective necroptosis inducer. The studies described herein demonstrate for the first time that functionalized biphenyl derivatives possess necroptosis inducer activity. Furthermore, these studies have led to the identification of two promising compounds (I; R = 4-OMe, R = 4-OEt) that can be used for further optimization studies as well as mechanism of action investigations. The experimental process involved the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Reference of 6-Bromopyridin-3-amine)
6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Reference of 6-Bromopyridin-3-amine