《Identification of the first potent, selective and bioavailable PPARα antagonist》 was written by Bravo, Yalda; Baccei, Christopher S.; Broadhead, Alex; Bundey, Richard; Chen, Austin; Clark, Ryan; Correa, Lucia; Jacintho, Jason D.; Lorrain, Daniel S.; Messmer, Davorka; Stebbins, Karin; Prasit, Peppi; Stock, Nicholas. Application of 13534-97-9This research focused ontriazolone containing biaryl sulfonamide preparation SAR PPAR alpha antagonist; Antagonist; Cancer; Fatty acid oxidation; Nuclear hormone receptor; PPAR alpha. The article conveys some information:
The discovery and SAR of a novel series of potent and selective PPARα antagonists are herein described. Exploration of replacements for the labile acyl sulfonamide linker led to a biaryl sulfonamide series of which compound I proved to be suitable for further profiling in vivo. Compound I demonstrated excellent potency, selectivity against other nuclear hormone receptors, and good pharmacokinetics in mouse. In the experimental materials used by the author, we found 6-Bromopyridin-3-amine(cas: 13534-97-9Application of 13534-97-9)
6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Application of 13534-97-9