Related Products of 2510-22-7In 2022 ,《Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis》 was published in Angewandte Chemie, International Edition. The article was written by Yang, Xiangbo; Lu, Huimin; Xie, Hang; Zhang, Binbin; Nie, Tianqing; Fan, Chen; Yang, Tao; Xu, Yechun; Su, Haixia; Tang, Wei; Zhou, Bing. The article contains the following contents:
Sepsis, characterized with high risk of life-threatening organ dysfunction, represents a major cause of health loss and the World Health Organization (WHO) labeled sepsis as the most urgent unmet medical need in 2017. The emerging biol. understanding of the role of RIPK1 in sepsis has opened up an exciting opportunity to explore potent and selective RIPK1 inhibitors as an effective therapeutic strategy for SIRS and sepsis therapy. Herein, we have synthesized a class of highly potent dual-mode RIPK1 inhibitors occupying both the allosteric and the ATP binding pockets, exemplified by compound 21 (ZB-R-55) which is about 10-fold more potent than GSK2982772, and exhibits excellent kinase selectivity, good oral pharmacokinetics and good therapeutic effects in the LPS-induced sepsis model, suggesting that compound ZB-R-55 is a highly promising preclin. candidate. The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7Related Products of 2510-22-7)
4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Related Products of 2510-22-7