HPLC of Formula: 29682-15-3In 2018 ,《Selectivity in the Intermolecular Diels-Alder Reaction of Conjugated Trienes: Experimental and Theoretical Approaches》 appeared in European Journal of Organic Chemistry. The author of the article were Remeur, Camille; Desrat, Sandy; Gandon, Vincent; Roussi, Fanny. The article conveys some information:
Eleven analogs of the natural product meiogynin A, an inhibitor of proteins of the Bcl-2 family, have been elaborated by an intermol. Diels-Alder (DA) reaction of various conjugated chloro-trienes, in order to determine the influence of the modification of the south part of meiogynin A on its biol. activity. The chloro-trienes were obtained in two to five steps from com. compounds through a selective hydrochlorination of bromoalkyne intermediates to (Z)-1,2-dihalogenated alkenes followed by a chemoselective Suzuki-Miyaura cross-coupling. The intermol. DA reaction of these trienes with two α,β-unsaturated carboxylic acids as dienophiles occurred with a perfect regioselectivity and good to excellent diastereoselectivities [e.g., I + II → III (87%, endo/exo 85:15)]. These selectivities could be rationalized by DFT calculationsMethyl 5-bromopicolinate(cas: 29682-15-3HPLC of Formula: 29682-15-3) was used in this study.
Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. HPLC of Formula: 29682-15-3