In 2019,European Journal of Organic Chemistry included an article by Tang, Shaojian; Wei, Wenjing; Yin, Dan; Poznik, Michal; Chruma, Jason J.. Application of 128071-75-0. The article was titled 《Palladium-Catalyzed Decarboxylative Generation and Propargylation of 2-Azaallyl Anions》. The information in the text is summarized as follows:
A palladium-catalyzed decarboxylative propargylation (DcPg) of propargyl 2,2-diphenylglycinate imines was developed for the synthesis of [((diphenylmethylene)amino)alkynyl]arenes (Ph2)C=NCH(Ar)CH2C≡CR [R = Me, Et, TMS; Ar = 4-CNC6H4, 2-BrC6H4, 3-pyridyl, etc.]. In this process, the nature of the propargyl ester and aryl imine components, as well as the catalyst system and solvent had a significant impact on the ratio of desired propargylated products vs. allene and/or diene side products that arose via different modes of C-C bond formation. The resulting propargylated products were transformed readily into useful (Z)-homoallylic amines. Moreover, the regioisomeric diene products could be converted to pharmaceutically-relevant diarylmethyl imines via a two-step Diels-Alder/oxidation process. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Application of 128071-75-0)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application of 128071-75-0