In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 875781-17-2, name is 5-Bromo-1H-pyrazolo[3,4-b]pyridine, the common compound, a new synthetic route is introduced below. Safety of 5-Bromo-1H-pyrazolo[3,4-b]pyridine
The 5-bromo -1H-pyrazolo [3,4-b] pyridine (2.0g, 10 . 1mmol) adding 20mLN, in N-dimethyl formamide, stirring to dissolve, then adding flaky potassium hydroxide (1.2g, 21 . 4mmol), stir at room temperature the reaction 10 minutes, and then added with the solid iodine (2.8g, 11 . 1mmol), stir at room temperature the reaction 4 experimental, then water (30 ml) dilution, ethyl acetate (3¡Á20 ml) extraction, then with saturated sodium thiosulfate solution (2¡Á30 ml) and saturated salt water (2¡Á30 ml) washing, the organic phase is dried with anhydrous sodium sulfate, concentrated. Then the solid plus dioxane (30 ml) is dissolved, add potassium hydroxide (1.2g, 21 . 4mmol), stir to react under room temperature for 10 minutes, then adding solid iodine (2.8g, 11 . 1mmol), stir at room temperature reaction sleepovers, water reaction is ended (30 ml) dilution, ethyl acetate (3¡Á20 ml) extraction, then with saturated sodium thiosulfate solution (2¡Á30 ml) and saturated salt water (2¡Á30 ml) washing, the organic phase is dried with anhydrous sodium sulfate, concentrated to obtain pale brown solid (2.8g, 85.6%).
The synthetic route of 875781-17-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai?Kechow Pharma, Inc; TIAN, HONGQI; JI, CONGHUI; HUANG, GONGCHAO; LIU, QIANG; (33 pag.)CN103613591; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem