Li, Guanglong; Xiao, Keya; Shi, Man; Shuai, Jing; Xu, Zhiping; Li, Zhong; Cheng, Jiagao published the artcile< Study on 4-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-d]pyrimidine Derivatives: Design, Synthesis, Insecticidal Assay and Binding Mode Studies>, HPLC of Formula: 3731-53-1, the main research area is oxotetrahydro pyrazolopyrimidine preparation insecticide docking SAR; GABA receptor; fipronil; insecticidal activity; phenylpyrazole; scaffold hopping.
A series of 4-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesized based on the fipronil low energy conformation by scaffold hopping strategy. Physicochem. properties calculation, insecticidal assay and binding mode studies were also performed. It was found that the target compounds displayed lower insecticidal activities than fipronil. The differences in binding modes between these compounds and fipronil may be the major reason for reduced insecticidal activities.
Chemistry & Biodiversity published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.