In 2018,Angewandte Chemie, International Edition included an article by Kim, Taehoon; McCarver, Stefan J.; Lee, Chulbom; MacMillan, David W. C.. Product Details of 53939-30-3. The article was titled 《Sulfonamidation of Aryl and Heteroaryl Halides through Photosensitized Nickel Catalysis》. The information in the text is summarized as follows:
Herein we report a highly efficient method for nickel-catalyzed C-N bond formation between sulfonamides and aryl electrophiles. This technol. provides generic access to a broad range of N-aryl and N-heteroaryl sulfonamide motifs, which are widely represented in drug discovery. Initial mechanistic studies suggest an energy-transfer mechanism wherein C-N bond reductive elimination occurs from a triplet excited NiII complex. Late-stage sulfonamidation in the synthesis of a pharmacol. relevant structure is also demonstrated. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Product Details of 53939-30-3)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Product Details of 53939-30-3