In 2022,Cheng, Heyong; Yang, Tingyuan; Edwards, Madison; Tang, Shuli; Xu, Shiqing; Yan, Xin published an article in Journal of the American Chemical Society. The title of the article was 《Picomole-Scale Transition Metal Electrocatalysis Screening Platform for Discovery of Mild C-C Coupling and C-H Arylation through in Situ Anodically Generated Cationic Pd》.Recommanded Product: 626-05-1 The author mentioned the following in the article:
Development of new transition metal-catalyzed electrochem. promises to improve overall synthetic efficiency. Here the authors describe the 1st integrated platform for online screening of electrochem. transition-metal catalysis. It uses the intrinsic electrochem. capabilities of nanoelectrospray ionization mass spectrometry (nano-ESI-MS) and picomole-scale anodic corrosion of a Pd electrode to generate and evaluate highly efficient cationic catalysts for mild electrocatalysis. The authors demonstrate the power of the novel electrocatalysis platform by (1) identifying electrolytic Pd-catalyzed Suzuki coupling at room temperature, (2) discovering Pd-catalyzed electrochem. C-H arylation in the absence of external oxidant or additive, (3) developing electrolyzed Suzuki coupling/C-H arylation cascades, and (4) achieving late-stage functionalization of two drug mols. by the newly developed mild electrocatalytic C-H arylation. More importantly, the scale-up reactions confirm that new electrochem. pathways discovered by nano-ESI can be implemented under the conventional electrolytic reaction conditions. This approach enables in situ mechanistic studies by capturing various intermediates including transient transition metal species by MS, and thus uncovering the critical role of anodically generated cationic Pd catalyst in promoting otherwise sluggish transmetalation in C-H arylation. The anodically generated cationic Pd with superior catalytic efficiency and novel online electrochem. screening platform hold great potentials for discovering mild transition-metal-catalyzed reactions. In the experiment, the researchers used many compounds, for example, 2,6-Dibromopyridine(cas: 626-05-1Recommanded Product: 626-05-1)
2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 626-05-1