In 2019,Journal of Coordination Chemistry included an article by Momeni, Badri Zaman; Fathi, Nastaran; Janczak, Jan; Shahsavari, Zahra. Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine. The article was titled 《Dihaloplatinum(II) complexes having diimine ligands: crystal structure, thermal properties, cytotoxicity effects against breast cancer cells and application as a precursor towards nanoparticles》. The information in the text is summarized as follows:
The reaction of potassium tetrachloroplatinate(II) with di-Me sulfide and a mixture of HBr/KBr affords trans-[PtBr2(SMe2)2]; [PtBr2(Me2bpy)] (Me2bpy = 4,4′-dimethyl-2,2′-bipyridine) was prepared from the reaction of trans-[PtBr2(SMe2)2] with Me2bpy. The crystal structure of the yellow form of [PtBr2(bu2bpy)] (bu2bpy = 4,4′-di-tert-butyl-2,2′-bipyridine) was determined by x-ray crystallog. The x-ray single-crystal structure determination of complex [PtBr2(bu2bpy)] reveals that the platinum adopts a square planar geometry with a twofold axis through the platinum atoms. Thermal properties of the related series of diimine platinum(II) complexes [PtX2(bu2bpy)] (X = Cl, Br, I) reveal that the thermal stabilities increase [PtI2(bu2bpy)] < [PtCl2(bu2bpy)] < [PtBr2(bu2bpy)]. [PtBr2(bpy)] (bpy = 2,2'-bipyridine), [PtBr2(Me2bpy)] and [PtX2(bu2bpy)] (X = Cl, Br, I) were studied by MTT assay against two human breast cancer cell lines of MCF-7 and MDA-MB-468 with [PtCl2(bu2bpy)] having a higher cytotoxic effect towards both cancer cell lines, which shows the significant role of the halide and diimine ligand. Semi-spherical Pt(0) nanoparticles (NPCs) were prepared by the simple calcination of [PtX2(bu2bpy)] (X = Cl, Br, I) at 800° in air. In the experiment, the researchers used many compounds, for example, 4,4'-Dimethyl-2,2'-bipyridine(cas: 1134-35-6Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine)
4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.