Electric Literature of 13466-38-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13466-38-1, name is 5-Bromopyridin-2-ol, molecular formula is C5H4BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Compound SM (1.73 g, 10 mol), 1-bromocyclopentane (1.79 g, 12 mmol) and cesium carbonate (6.52 g,20 mmol) was dissolved in 10 mL of DMF and reacted at 90 C overnight. The reaction is completed,Diluted with water and extracted three times with ethyl acetate. The organic phases were combined and washed three times with water.Wash once with saturated brine, dry over anhydrous sodium sulfate, and filter.The solvent was evaporated under reduced pressure, and the obtained oil was purified to give 5-bromo-1-cyclopentylpyridine-2(1H)-one (459 mg, yield 20%,White solid).
According to the analysis of related databases, 13466-38-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Liu Gang; Luo Xiaoyong; Dong Zhenwen; Li Xiaoyong; Yu Hua; Zeng Hong; Song Hongmei; Wang Ying; Wang Lichun; Wang Jingyi; (49 pag.)CN109293652; (2019); A;,
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