Related Products of 53939-30-3In 2019 ,《Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT)》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Palacios, Daniel S.; Meredith, Erik L.; Kawanami, Toshio; Adams, Christopher M.; Chen, Xin; Darsigny, Veronique; Palermo, Mark; Baird, Daniel; George, Elizabeth L.; Guy, Chantale; Hewett, Jeffrey; Tierney, Laryssa; Thigale, Sachin; Wang, Louis; Weihofen, Wilhelm A.. The article conveys some information:
Small mols. that inhibit the metabolic enzyme NAMPT have emerged as potential therapeutics in oncol. As part of our effort in this area, we took a scaffold morphing approach and identified 3-pyridyl azetidine ureas as a potent NAMPT inhibiting motif. We explored the SAR of this series, including 5 and 6 amino pyridines, using a convergent synthetic strategy. This lead optimization campaign yielded multiple compounds with excellent in vitro potency and good ADME properties that culminated in compound 27.5-Bromo-2-chloropyridine(cas: 53939-30-3Related Products of 53939-30-3) was used in this study.
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Related Products of 53939-30-3