《Peptide-Conjugated Long-Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells》 was written by Wang, Wanhe; Wu, Ke-Jia; Vellaisamy, Kasipandi; Leung, Chung-Hang; Ma, Dik-Lung. Category: pyridine-derivatives And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:
Gastrin-releasing peptide receptor (GRPr) plays proliferative and inflammatory roles in living systems. Here, the authors report a highly selective GRPr antagonist (JMV594)-tethered iridium(III) complex for probing GRPr in living cancer cells and immune cells. This probe exhibited desirable photophys. properties and also displayed negligible cytotoxicity, overcoming the inherent toxicity of the iridium(III) complex. Its long emission lifetime enabled its luminescence signal to be readily distinguished from the interfering fluorescence of organic dyes by using a time-resolved technique. This probe selectively visualized living cancer cells via specific binding to GRPr, while it also modulated the function of GRPr on TNF-α secretion in immune cells. To the authors′ knowledge, this is the first peptide-conjugated iridium(III) complex developed as a GRPr bioimaging probe and modulator of GRPr activity. This theranostic agent shows great potential at unmasking the diverse roles of GRPr in living systems. The results came from multiple reactions, including the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Category: pyridine-derivatives)
4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Category: pyridine-derivatives Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.