Adding a certain compound to certain chemical reactions, such as: 122368-54-1, 2-((4-Chlorophenyl)(piperidin-4-yloxy)methyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 122368-54-1, blongs to pyridine-derivatives compound. Product Details of 122368-54-1
To 10 mL of DMF were added 0.5 g of vanillic acid, 0.51 g of EDC, 0.44 g of HOBt, 1.44 mL of TEA and 0.99 g of 2-[(4-chlorophenyl)(4-piperidinyloxy)methyl]pyridine, and the mixture was stirred at 60 to 80C for 4 hours. 10 mL of EtOAc and 10 mL of purified water were added to the reaction mixture and the layers were separated. The aqueous layer was extracted once with 10 mL of EtOAc and the aqueous layer was discarded. The organic layer was washed three times with 10 mL of purified water, dried over Na2SO4 and filtered. The filtrate was distilled under reduced pressure and purified by flash column chromatography to obtain 0.40 g of the title compound as a pale yellow solid. Yield: 31.6% 1H NMR (400MHz, DMSO-d6) delta 9.41 (brs, 1H), 8.47 (d, J = 4.0 Hz, 1H), 7.81 (t, J = 7.0, 1H), 7.57(d, J = 8.0 Hz, 1H), 7.44?6.94(m, 6H), 6.84?6.67(m, 3H), 5.71(s, 1H), 3.87(s, 3H), 3.74?3.69(m, 2H), 3.37(brs, 2H), 1.85(brs, 2H), 1.72(brs, 2H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,122368-54-1, its application will become more common.
Reference:
Patent; Shin Poong Pharmaceutical Co., Ltd.; RYU, JeiMan; LEE, Dong Won; LEE, Kang Hyeok; PARK, Jin Hun; CHO, Geum Sil; LEE, Ki Sung; CHUNG, Jin Ho; PARK, Woo Ile; LEE, Jae Young; (35 pag.)EP3345910; (2018); A1;,
Pyridine – Wikipedia,
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