Recommanded Product: 1206978-15-5On November 30, 2017 ,《Tri- and difluoromethoxylated N-based heterocycles – Synthesis and insecticidal activity of novel F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid》 appeared in Journal of Fluorine Chemistry. The author of the article were Landelle, Gregory; Schmitt, Etienne; Panossian, Armen; Vors, Jean-Pierre; Pazenok, Sergiy; Jeschke, Peter; Gutbrod, Oliver; Leroux, Frederic R.. The article conveys some information:
The preparation of F3CO- and F2HCO-analogs of Imidacloprid and Thiacloprid, I (R = CF3, CHF2) and II, resp., and the evaluation of their biol. activity have been performed. For this purpose, a first synthetic approach allowed the preparation of a desired F3CO-containing key intermediate, 3-(chloromethyl)-6-(trifluoromethoxy)pyridine. To allow facile access to the corresponding F2HCO-containing key intermediate, the difluoromethylation of hydroxylated N-based heterocycles has been developed using difluoromethyl triflate (a liquid non-ODS reagent) under air in aqueous conditions and with very short reaction time. The broad diversity of compatible heterocycles includes a large series of substituted hydroxy-pyridines, but also -pyrazoles, -pyrazine, -pyridazine, and -quinolines. The couplings of both key intermediates with the required 4,5-dihydro-N-nitro-1H-imidazol-2-amine and [N(Z)]-N-2-thiazolidinylidene-cyanamide were successfully achieved using literature conditions. This work enables the preparation of valuable building blocks, which could lead to the discovery of new bioactive entities. In the part of experimental materials, we found many familiar compounds, such as 2-Chloro-4-(difluoromethoxy)pyridine(cas: 1206978-15-5Recommanded Product: 1206978-15-5)
2-Chloro-4-(difluoromethoxy)pyridine(cas: 1206978-15-5) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 1206978-15-5