《Studies on anticoccidial agents. 11. Synthesis and anticoccidial activity of nitropyridinecarboxamides and derivatives》 was published in Journal of Medicinal Chemistry in 1977. These research results belong to Morisawa, Yasuhiro; Kataoka, Mitsuru; Kitano, Noritoshi. Electric Literature of C6H4N2O4 The article mentions the following:
Of 56 title compounds prepared, optimal in vivo activity against Eimeria tenella was shown by 2-nitroisonicotinamide (I, R1 = R2 = H) [60780-17-8] and 11 derivatives (I: R1 = H, Me; R2 = Me, CH2OH, alkanoyl, aryl acyl, heterocyclic acyl). Activity was shown by 2-, 3-, 5-, and 6-nitro-, but not by 4-nitropyridinecarboxamides. Substitution on the amide N of the various positional isomers affected their activity differently. In the part of experimental materials, we found many familiar compounds, such as 3-Nitroisonicotinic acid(cas: 59290-82-3Electric Literature of C6H4N2O4)
3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Electric Literature of C6H4N2O4