《Copper-Catalyzed Enantioselective Three-Component Synthesis of Optically Active Propargylamines from Aldehydes, Amines, and Aliphatic Alkynes》 was published in Chemistry – A European Journal in 2010. These research results belong to Nakamura, Shuichi; Ohara, Mutsuyo; Nakamura, Yuko; Shibata, Norio; Toru, Takeshi. COA of Formula: C35H27N3O2 The article mentions the following:
An enantioselective three-component reaction of aldehydes, amines, and aliphatic alkynes catalyzed by C2-sym. pybim Cu1 catalysts to give propargylamines, e.g., I in good yields and with high enantioselectivity has been developed. This process has many advantages, such as simplified operation and mild reaction conditions. These results open a novel way to synthesize optically active propargylamines. In the experiment, the researchers used many compounds, for example, 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7COA of Formula: C35H27N3O2)
2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. COA of Formula: C35H27N3O2The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.