Rani, Chekuri Sharmila; Reddy, Alugubelli Gopi; Susithra, E.; Mak, Kit-Kay; Pichika, Mallikarjuna Rao; Reddymasu, Sreenivasulu; Rao, Mandava Venkata Basaveswara published their research in Medicinal Chemistry Research in 2021. The article was titled 《Synthesis and anticancer evaluation of amide derivatives of imidazo-pyridines》.Computed Properties of C5H3Br2N The article contains the following contents:
Abstract: A novel series of amide functionalized imidazo[1,2-a]pyridine (14a-14j) derivatives were synthesized and screened for their anticancer activities against breast (MCF-7 and MDA-MB-231), lung (A549), and prostate (DU-145) cancer cell lines using MTT assay with etoposide as the standard reference drug. Among them, compound 14 showed highest potency in anticancer activities against MCF-7, MDA-MB-231, A549, and DU-145 cell lines with IC50 values of 0.021 ± 0.0012μM, 0.95 ± 0.039μM, 0.091 ± 0.0053μM, and 0.24 ± 0.032μM, resp. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromopyridine(cas: 624-28-2Computed Properties of C5H3Br2N)
2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Computed Properties of C5H3Br2N