Formula: C5H5BrN2On May 19, 2022 ,《Base-Mediated Remote Deuteration of N-Heteroarenes – Broad Scope and Mechanism》 appeared in European Journal of Organic Chemistry. The author of the article were Kopf, Sara; Liu, Jiali; Franke, Robert; Jiao, Haijun; Neumann, Helfried; Beller, Matthias. The article conveys some information:
Using KOtBu as base and DMSO-d6 as deuterium source, a general and applicable method was presented for the selective deuteration of a set of nitrogen-containing heterocycles (pyridines, azines and bioactive mols.). Exptl. and DFT mechanistic studies indicated that this reaction proceeded via deprotonation of the substrates by the dimsyl anion. The relative thermodn. stability of the heterocycle anions determines the distribution and degree of deuteration. In the experiment, the researchers used 2-Bromopyridin-3-amine(cas: 39856-58-1Formula: C5H5BrN2)
2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Formula: C5H5BrN2