Electric Literature of C6H4BrNOIn 2019 ,《An approach to the synthesis of 3-substituted piperidines bearing partially fluorinated alkyl groups》 was published in Journal of Fluorine Chemistry. The article was written by Subota, Andrii I.; Ryabukhin, Sergey V.; Gorlova, Alina O.; Grygorenko, Oleksandr O.; Volochnyuk, Dmitriy M.. The article contains the following contents:
An approach to the synthesis of 3-substituted piperidines bearing partially fluorinated alkyl groups I [X = Y = H, F; R = H, Me, i-Pr] was proposed. The method was based on the DAST-mediated nucleophilic fluorination of easily available 2-bromopyridin-3-yl alcs. and ketones affording 2-bromo-3-(1-fluoroalkyl)pyridines and 2-bromo-3-(1,1-difluoroalkyl)pyridines II [R1 = H, Me, i-Pr, Ph; R2 = H, F], followed by catalytic hydrogenation. The hydrogenation step was studied with common heterogeneous Pd-, Pt-, and Rh-based catalyst. It was found that in the case of fluoroalkyl derivatives, the pyridine core reduction was accompanied by hydrodefluorination, which became a limitation of the strategy. Nevertheless, the method worked well with 1,1-difluoroalkyl derivatives The results came from multiple reactions, including the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Electric Literature of C6H4BrNO)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Electric Literature of C6H4BrNO