Dong, Dong; Thomas, Nicky; Ramezanpour, Mahnaz; Psaltis, Alkis J.; Huang, Shuman; Zhao, Yulin; Thierry, Benjamin; Wormald, Peter-John; Prestidge, Clive A.; Vreugde, Sarah published the artcile< Inhibition of Staphylococcus aureus and Pseudomonas aeruginosa biofilms by quatsomes in low concentrations>, Name: 1-Hexadecylpyridin-1-ium chloride, the main research area is Staphylococcus Pseudomonas biofilm quatsome; CPC-quatsome; Chronic rhinosinusitis; Pseudomonas aeruginosa; Staphylococcus aureus; biofilm; cetylpyridinium chloride.
This study investigated the inhibition effect of cetylpyridinium chloride (CPC)-quatsomes at low concentrations on both S. aureus and P. aeruginosa biofilms in vitro, as well as their toxicities towards cultured human airway epithelial (NuLi-1) cells. CPC-quatsome and CPC micelle solutions at concentrations of 0.01%, 0.025%, and 0.05% were prepared Confocal laser scanning microscopy (CLSM) was used to investigate the interactions between CPC-quatsomes and S. aureus and P. aeruginosa biofilms. A lactate dehydrogenase (LDH) assay was used to determine the toxicity of CPC-quatsomes on NuLi-1 cells. CPC-quatsome and CPC micelle solutions had significant inhibition effects at all tested concentrations on planktonic S. aureus and P. aeruginosa and their biofilms. In the CLSM study, different interactions between CPC-quatsomes and S. aureus or P. aeruginosa biofilms were observed CPC-quatsomes at low concentrations inhibited S. aureus and P. aeruginosa in both planktonic form and biofilms. No adverse effects on NuLi-1 cells were observed, indicating their promising potential in the treatment of CRS. In our study, CPC-quatsomes at concentrations of 0.01%, 0.025%, and 0.05% had significant inhibition effects on both planktonic and biofilms of S. aureus and P. aeruginosa. The result of this study indicates the promising potential of CPC-quatsome in the treatment of CRS.
Experimental Biology and Medicine (London, United Kingdom) published new progress about Biofilms (microbial). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Name: 1-Hexadecylpyridin-1-ium chloride.