Takeuchi, Toshifumi; Mori, Kisho; Sunayama, Hirobumi; Takano, Eri; Kitayama, Yukiya; Shimizu, Taku; Hirose, Yuzuki; Inubushi, Sachiko; Sasaki, Ryohei; Tanino, Hirokazu published the artcile< Antibody-Conjugated Signaling Nanocavities Fabricated by Dynamic Molding for Detecting Cancers Using Small Extracellular Vesicle Markers from Tears>, Name: 1,2-Di(pyridin-2-yl)disulfane, the main research area is antibody breast cancer diagnosis extracellular vesicle marker tear.
Small extracellular vesicles (sEVs) are reliable biomarkers for early cancer detection; however, conventional detection methods such as immune-based assays and microRNA analyses are not very sensitive and require sample pretreatments and long anal. time. Here, the authors developed a mol. imprinting-based dynamic molding approach to fabricate antibody-conjugated signaling nanocavities capable of size recognition. This enabled the establishment of an easy-to-use, rapid, sensitive, pretreatment-free, and noninvasive sEV detection platform for efficient sEV detection-based cancer diagnosis. An apparent dissociation constant was estimated to be 2.4 × 10-16 M, which was ~1000 times higher than that of com. immunoassays (anal. time, 5 min/sample). The authors successfully used tears for the first time to detect cancer-related intact sEVs, clearly differentiating between healthy donors and breast cancer patients, as well as between samples collected before and after total mastectomy. The nanoprocessing strategy can be easily repurposed for the specific detection of other types of cancer by changing the conjugated antibodies, thereby facilitating the establishment of liquid biopsy for early cancer diagnosis.
Journal of the American Chemical Society published new progress about Antibodies and Immunoglobulins Role: ARG (Analytical Reagent Use), BUU (Biological Use, Unclassified), DGN (Diagnostic Use), ANST (Analytical Study), USES (Uses), BIOL (Biological Study). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Name: 1,2-Di(pyridin-2-yl)disulfane.