Halevas, Eleftherios; Pekou, Anna; Papi, Rigini; Mavroidi, Barbara; Hatzidimitriou, Antonios G.; Zahariou, Georgia; Litsardakis, George; Sagnou, Marina; Pelecanou, Maria; Pantazaki, Anastasia A. published the artcile< Synthesis, physicochemical characterization and biological properties of two novel Cu(II) complexes based on natural products curcumin and quercetin>, Formula: C10H8N2, the main research area is copper curcumin quercetin bipyridine complex preparation crystal mol structure; antioxidant antiinflammatory DNA binding cleavage copper curcumin quercetin complex; Antioxidant activity; Copper complexes; Curcumin; DNA plasmid binding; Quercetin.
Curcumin and quercetin are two of the most prominent natural polyphenols with a diverse spectrum of beneficial properties, including antioxidant, anti-inflammatory, chemopreventive and chemotherapeutic activity. The complexation of these natural products with bioactive transition metal ions can lead to the generation of novel metallodrugs with enhanced biochem. and pharmacol. activities. Within this framework, the synthesis and detailed structural and physicochem. characterization of two novel complex assemblies of Cu(II) with curcumin and quercetin and the ancillary aromatic chelator 2,2′-bipyridine is presented. The two complexes represent the only crystallog. characterized structures with Cu(II) as the central metal ion and curcumin or quercetin as the ligands. The new complexes were biol. evaluated in vitro for their antioxidant potential, both exhibiting strong scavenging activity in the 2,2-diphenyl-1-picrylhydrazyl assay, and their plasmid DNA binding/cleavage properties. Both complexes appear to be non-toxic in the eukaryotic exptl. model Saccharomyces cerevisiae and merit further investigation of their pharmacol. profile.
Journal of Inorganic Biochemistry published new progress about Anti-inflammatory agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Formula: C10H8N2.