Stockmann, Vegar; Fiksdahl, Anne published the artcile< Synthesis of novel 1,7-naphthyridines by Friedlaender condensation of pyridine substrates>, Recommanded Product: 3-Aminoisonicotinaldehyde, the main research area is naphthyridine pyridinyl aryl preparation Friedlaender.
The general ability of appropriate pyridyl compounds (aldehyde or ketone) to undergo Friedlaender condensation to give different 1,7-naphthyridines has been demonstrated. 2-(4-Pyridinyl)-4-methyl-1,7-naphthyridine was prepared from 3-amino-4-acetylpyridine (I) and 4-acetylpyridine (82%). The Friedlaender self-condensation of I is also reported. 2-(3-Aminopyridin-4-yl)-4-methyl-1,7-naphthyridine was obtained in 97% yield. 2-Aryl- and 2,3-diaryl-1,7-naphthyridines were prepared from 3-aminoisonicotinaldehyde (II) and aryl ketones (28-71%). The key substrates I and II are readily available via the improved pyridine nitration method.
Journal of Heterocyclic Chemistry published new progress about Friedlander synthesis. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Recommanded Product: 3-Aminoisonicotinaldehyde.