Application of 168823-76-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 168823-76-5, name is 5-Bromo-2-(chloromethyl)pyridine. A new synthetic method of this compound is introduced below.
Example A50 Preparation of intermediate 50: (5-Bromo-pyridin-2-yl)-acetonitrile Potassium cyanide (0.489 g, 7.41 mmol) and potassium iodide (0.013 g, 0.079 mmol) were added to a stirred solution of 5-bromo-2-chloromethyl-pyridine (0.9 g, 3.70 mmol) (obtained by procedures similar to those described in, van den Heuvel, M. et al.; J. Org. Chem., 2004, 250) in a mixture of ethanol (6 ml) and water (2 ml). The mixture was stirred at 80 C. for 6 h., then diluted with dichloromethane and washed with a saturated solution of sodium hydrogen carbonate. The organic layer was separated, dried (Na2SO4), filtered and the solvents evaporated in vacuo. The crude product was purified by flash column chromatography (silica; dichloromethane). The desired fractions were collected and concentrated in vacuo to yield intermediate 50 (0.498 g, 68%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,168823-76-5, 5-Bromo-2-(chloromethyl)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; Pastor-Fernandez, Joaquin; Bartolome-Nebreda, Jose Manuel; Macdonald, Gregor James; Conde-Ceide, Susana; Delgado-Gonzalez, Oscar; Vanhoof, Greta Constantia Peter; Van Gool, Michiel Luc Maria; Martin-Martin, Maria Luz; Alonso-de Diego, Sergio-Alvar; Swinney, Kelly Ann; Leys, Carina; Weerts, Johan Erwin Edmond; Wuyts, Stijn; US2011/269752; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem