Ma, Teng; Chen, Yate; Li, Yuxiu; Ping, Yuanyuan; Kong, Wangqing published the artcile< Nickel-Catalyzed Enantioselective Reductive Aryl Fluoroalkenylation of Alkenes>, Recommanded Product: (R)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole, the main research area is nickel catalyzed enantioselective reductive aryl monofluoroalkenylation alkene; aryl bromide gem difluoroalkene monofluoroalkenylation; oxindole monofluoroalkenyl substituent preparation.
Enantioselective Ni-catalyzed reductive aryl monofluoroalkenylation of alkenes between aryl bromides and gem-difluoroalkenes has been developed. The reaction proceeding under room temperature and base-free reaction conditions tolerates a wide range of functional groups on both coupling partners. Various synthetically useful oxindoles containing monofluoroalkenyl substituent are obtained in good yields with 85%-95% enantiomeric excess. In addition, the synthetic method can be further applied to the late-stage monofluoroalkenylation of complex biol. active compounds
ACS Catalysis published new progress about Alkenylation (monofluoro-). 1428537-19-2 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Recommanded Product: (R)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole.