Dziuganowska, Zofia A.; Slepokura, Katarzyna; Volle, Jean-Noel; Virieux, David; Pirat, Jean-Luc; Kafarski, Pawel published the artcile< Structural Analogues of Selfotel>, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate, the main research area is phosphonate pyridinecarboxylic piperidinecarboxylic preparation phosphonylation bromopyridine hydrogenation; NMDA antagonist library phosphonate pyridinecarboxylic piperidinecarboxylic acid preparation activity; crystal structure phosphonate pyridinecarboxylic piperidinecarboxylic acid NMDA antagonist; mol structure phosphonate pyridinecarboxylic piperidinecarboxylic acid NMDA antagonist.
A small library of phosphonopiperidylcarboxylic acids, analogs of NMDA antagonist selfotel (CGS 19755), was synthesized. First, the series of aromatic esters was obtained via a palladium-catalyzed cross-coupling reaction (Hirao coupling) of dialkyl phosphites with bromopyridinecarboxylates, followed by their hydrolysis. Then, hydrogenation of the resulting phosphonopyridylcarboxylic acids over PtO2 yielded the desired phosphonopiperidylcarboxylic acids. NMR studies indicated that the hydrogenation reaction proceeds predominantly by cis addition Several compounds were obtained as monocrystal structures. Preliminary biol. studies performed on cultures of neurons suggest that the obtained compounds possess promising activity toward NMDA receptors.
Journal of Organic Chemistry published new progress about Carboxylic esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate.