Malik, Magdalena; Bienko, Dariusz C.; Komarnicka, Urszula K.; Kyziol, Agnieszka; Drys, Magdalena; Switlicka, Anna; Dyguda-Kazimierowicz, Edyta; Jedwabny, Wiktoria published an article in 2021. The article was titled 《Synthesis, structural characterization, docking simulation and in vitro antiproliferative activity of the new gold(III) complex with 2-pyridineethanol》, and you may find the article in Journal of Inorganic Biochemistry.Name: 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:
Gold(III) complex containing 2-pyridineethanol has been synthesized and characterized structurally by single crystal X-ray diffraction, vibrational spectroscopy, 1H NMR spectroscopy, electrochem. study, and DFT calculations The Au(III) ion is four coordinated with one N-donor ligand (L) and three Cl anions. The Okuniewski′s has been used to estimate the angular distortion from ideal square planar geometry. The vibrational spectroscopy studies, in the solid state and DMSO solution and cyclic voltammetry, have been performed to determine its stability and redox activity, resp. A complete assignment of the IR and Raman spectra has been made based on the calculated potential energy distribution (PED). The theor. calculations have been made for two functionals and several basis sets. The compound has been evaluated for its antiproliferative properties in a human lung adenocarcinoma cell line (A549), mouse colon carcinoma (CT26), human breast adenocarcinoma (MCF-7), human prostate carcinoma derived from the metastatic site in the brain (DU-145), and PANC-1 human pancreas/duct carcinoma cell line and non-tumorigenic cell lines: HaCat (human keratinocyte), and HEK293T (human embryonic kidney). Au(III) complex cytotoxicity is significantly against A549 and MCF-7 cells as in the reference drug: cisplatin. Studies of the interactions of Au(III) complex with DNA, HSA (human serum albumin) have been performed. The results from modeling docking simulations indicate that the title complex exerts anticancer effects in vitro based on different mechanisms of action to compare with cisplatin. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Name: 2-(2-Hydroxyethyl)pyridine)
2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Name: 2-(2-Hydroxyethyl)pyridine