《Picolinic Acid, a Catabolite of Tryptophan, Has an Anabolic Effect on Bone In Vivo》 was written by Duque, Gustavo; Vidal, Christopher; Li, Wei; Al Saedi, Ahmed; Khalil, Mamdouh; Lim, Chai K.; Myers, Damian E.; Guillemin, Gilles J.. SDS of cas: 98-98-6 And the article was included in Journal of Bone and Mineral Research in 2020. The article conveys some information:
Fractures attributable to osteoporosis have a severe impact on our older population. Reports of side effects with commonly prescribed osteoporosis drugs have led to the investigation of new and safer treatments with novel mechanisms of action. Picolinic acid (PIC), a catabolite of tryptophan, induces in vitro osteogenic differentiation of mesenchymal stem cells. Here we demonstrate that PIC has an anabolic effect on bone in vivo by increasing bone formation, bone mass, and bone strength in normal and ovariectomized C57BL/6 mice. Activation of the osteogenic pathways triggered this osteoanabolic response without any cross-related effects on mineral absorption or calciotropic hormones. Because PIC was also well tolerated and absorbed with no side effects, it is an ideal potential candidate for the treatment of osteoporosis. After reading the article, we found that the author used Picolinic acid(cas: 98-98-6SDS of cas: 98-98-6)
Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.SDS of cas: 98-98-6