In 2019,Drug and Chemical Toxicology (1977) included an article by Varol, Mehmet; Benkli, Kadriye; Koparal, Ayse T.; Bostancioglu, Rakibe B.. Name: 4,4′-Dimethyl-2,2′-bipyridine. The article was titled 《Design and synthesis of novel organometallic complexes using boronated phenylalanine derivatives as potential anticancer agents》. The information in the text is summarized as follows:
Drug design and discovery studies are important because of the prevalence of diseases without available medical cures. New anticancer agents are particularly urgent because of the high mortality rate associated with cancer. A series of mononuclear gold (III) and platinum (II) complexes based on boronated phenylalanine (BPA) were designed and synthesized using 4,4′-dimethyl-2,2′-dipyridyl (L1) or 1,10-phenanthroline-5,6-dion (L2) ligands to obtain promising anticancer drug candidates. Proton NMR, IR, mass spectrometry, and elemental analyses were utilized for chem. characterizations. Cell viability, cancer cell colony formation, endothelial tube formation, and cytoskeleton staining assays were performed using A549 lung adenocarcinoma and human umbilical vein endothelial cells (HUVECs) to investigate preliminary pharmacol. activities. L1-based platinum (II) complex (BPA-L1-Pt) was the most promising complex, and has similar activity with the approved chemotherapy drug cis-platinum. Half maximal inhibitory concentration values for BPA-L1-Pt were 9.15 μM on A549s and 16.61 μM on HUVECs; the values for cis-platinum were 5.24 μM on A549s and 23.14 μM on HUVECs. Consequently, further synthesis studies should be performed to boost the cancer cell selectivity feature of BPA by varying metal and ligand types. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Name: 4,4′-Dimethyl-2,2′-bipyridine)
4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Name: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.