Reference of 153034-94-7 , The common heterocyclic compound, 153034-94-7, name is 2-Fluoro-4-iodo-5-picoline, molecular formula is C6H5FIN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Preparation 18; 4-Benzo[¡ê]thiophen-7-yl-2-fluoro-5-methyl-pyridine; In a flask, combine 2-fluoro-4-iodo-5-methyl-pyridine (355 mg, 1.5 mmol), 2- benzo[¡ê]thiophen-7-yl-4,4,5,5-tetramethyl-[l,3,2]dioxaborolane (282 mg, 1.8 mmol), [l,r-bis(diphenylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane (1: 1) (61 mg, 0.07 mmol), 2-(di-tert-butylphosphino)biphenyl (13 mg, 0.04 mmol), sodium carbonate (2 M, 1.5 mL, 3 mmol) and THF (10 mL). Heat the mixture at 100 0C for 3 hours in an oil bath. Dilute the mixture with chloroform/isopropanol (3/1). Wash the solution with saturated aqueous sodium chloride. Dry over sodium sulfate. Concentrate in vacuo to a dark residue. Purify by column chromatography (20 % ethyl acetate in hexane) to afford the title compound (300 mg, 82 %) as yellow oil. MS (ES) m/z 244 [M+ 1]+.
The synthetic route of 153034-94-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELI LILLY AND COMPANY; WO2008/76704; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem