《Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors》 was written by Huang, Chunhui; Fischer, Christian; Machacek, Michelle R.; Bogen, Stephane; Biftu, Tesfaye; Huang, Xianhai; Reutershan, Michael H.; Otte, Ryan; Hong, Qingmei; Wu, Zhicai; Yu, Yang; Park, Min; Chen, Lei; Biju, Purakkattle; Knemeyer, Ian; Lu, Ping; Kochansky, Christopher J.; Hicks, Michael Brendan; Liu, Yong; Helmy, Roy; Fradera, Xavier; Donofrio, Anthony; Close, Josh; Maddess, Matthew L.; White, Catherine; Sloman, David L.; Sciammetta, Nunzio; Lu, Jun; Gibeau, Craig; Simov, Vladimir; Zhang, Hongjun; Fuller, Peter; Witter, David. Recommanded Product: 128071-75-0This research focused ontricyclic diazepine preparation SAR mutant isocitrate dehydrogenase inhibitor. The article conveys some information:
Efforts to reduce the electron-rich nature of the core were described. Ultimately, a strategy focused on core modifications to block metabolic hot spots coupled with substitution pattern changes (C8 N → C linked) led to the identification of new tricyclic analogs such as I (R1 = 1-aza-4-oxa[2.2.2]bicyclooctyl; R2 = trans-4-isopropoxycyclohexyl) with minimal GSH-adduct formation across species while maintaining an overall balanced profile.2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0) was used in this study.
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 128071-75-0