COA of Formula: C7H7NOIn 2020 ,《Copper-catalyzed formal [1 + 2 + 2]-annulation of alkyne-tethered diazoacetates and pyridines: access to polycyclic indolizines》 appeared in Organic & Biomolecular Chemistry. The author of the article were Dong, Shanliang; Huang, Jingjing; Sha, Hongkai; Qiu, Lihua; Hu, Wenhao; Xu, Xinfang. The article conveys some information:
A copper-catalyzed formal [1 + 2 + 2] annulation of alkyne-tethered diazo compounds with pyridines afforded polycyclic fused indolizines in good yields under mild reaction conditions was reported. This method features the use of an inexpensive copper catalyst and readily available starting materials, broad substrate generality and operational simplicity. Notably, a variety of natural product derivatives were compatible under the current conditions, which showed significant potential of this method for the selective decoration and modification of analogous biomols. or pharmaceuticals. In the experiment, the researchers used 4-Acetylpyridine(cas: 1122-54-9COA of Formula: C7H7NO)
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.COA of Formula: C7H7NO