Related Products of 71255-09-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.71255-09-9, name is 2-Methoxynicotinaldehyde, molecular formula is C7H7NO2, molecular weight is 137.14, as common compound, the synthetic route is as follows.
General procedure: The ketone or aldehyde (0.72mmol) was added to a stirred solution of amine (0.63mmol, HCl salt) and acetic acid (0.68mmol) in 10mL DCE with ice cooling. After stirring for 10minat rt, sodium triacetoxyborohyride (1.26mmol) was added to the reaction mixture. After stirring at for 6h, the reaction mixture was diluted with dichloromethane (50mL), washed with saturated sodium bicarbonate solution, brine, dried over MgSO4, filtered, and concentrated under vacuum. The residue was purified by silica gel column chromatography to give the N-alkylated product.
The chemical industry reduces the impact on the environment during synthesis 71255-09-9, I believe this compound will play a more active role in future production and life.
Reference:
Article; Ji, Yue-Yang; Lin, Sen-Dong; Wang, Yu-Jie; Su, Ming-Bo; Zhang, Wei; Gunosewoyo, Hendra; Yang, Fan; Li, Jia; Tang, Jie; Zhou, Yu-Bo; Yu, Li-Fang; European Journal of Medicinal Chemistry; vol. 141; (2017); p. 101 – 112;,
Pyridine – Wikipedia,
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