Formula: C5H5BrN2In 2018 ,《Ligand-free Iron(II)-Catalyzed N-Alkylation of Hindered Secondary Arylamines with Non-activated Secondary and Primary Alcohols via a Carbocationic Pathway》 was published in Advanced Synthesis & Catalysis. The article was written by Nayal, Onkar S.; Thakur, Maheshwar S.; Kumar, Manoranjan; Kumar, Neeraj; Maurya, Sushil K.. The article contains the following contents:
Secondary benzylic alcs. represent a challenging class of substrates for N-alkylation of amines. Herein, the authors describe an iron(II)-catalyzed eco-friendly protocol for N-alkylation of secondary arylamines with secondary benzyl alcs. through a carbocationic pathway instead of the known borrowing hydrogen transfer (BHT) approach. Transiently generated carbocations, produced from alcs. via self-condensation, were coupled with arylamines to provide highly functionalized amine products. The scope of this methodol. involves N-alkylation of primary, secondary and heterocyclic amines with primary/secondary benzylic, allylic and heterocyclic alcs., which are common key structures in numerous pharmaceuticals drugs. The method can also be easily adopted for the amination of various natural products. In the experimental materials used by the author, we found 6-Bromopyridin-3-amine(cas: 13534-97-9Formula: C5H5BrN2)
6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Formula: C5H5BrN2