Computed Properties of C12H12N2In 2020 ,《A paramagnetic oxalato-bridged binuclear copper(II) complex as an effective catalase inhibitor. Spectroscopic and molecular docking studies》 appeared in Journal of Molecular Structure. The author of the article were Shahraki, Somaye; Razmara, Zohreh; Shiri, Fereshteh. The article conveys some information:
A binuclear oxalato-bridged Cu complex formulated as [μ-(ox){Cu(Mebpy) (NO3) (H2O)} 2] (Mebpy is 5,5′-dimethyl-2,2′-dipyridyl and ox is oxalate) was synthesized through an environment-friendly reaction under ultrasound irradiation This complex was selected to study its mol. interactions with bovine liver catalase (BLC) using exptl. and mol. modeling methods. The enzymic activity of BLC decreased to 34.6% when the concentration of the above complex is 9.0 × 10-5 M. The fluorescence results showed that Cu complex could bind with BLC with a relatively strong affinity (Kb = 2.61 and 2.67 × 107 M-1 at 300 and 310 K, resp.). Due to Cu complex interactions, the intrinsic fluorescence of the BLC was quenched by a static quenching mechanism and hydrogen bonds and van der Waals forces were the main active forces in the interaction process. The results of mol. modeling were in good agreement with the exptl. data and showed that there is one binding site for Cu complex on BLC. Also, the in vitro antioxidant activity of the Cu complex was evaluated against 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH.). Cu complex presented moderate antioxidant activity (IC50 = 25 mg L-1) in comparison with ascorbic acid. In addition to this study using 4,4′-Dimethyl-2,2′-bipyridine, there are many other studies that have used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Computed Properties of C12H12N2) was used in this study.
4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Computed Properties of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.