In 2022,Mahato, Shreya; Rawal, Parveen; Devadkar, Ajitrao Kisan; Joshi, Mayank; Roy Choudhury, Angshuman; Biswas, Bhaskar; Gupta, Puneet; Panda, Tarun K. published an article in Organic & Biomolecular Chemistry. The title of the article was 《Hydroboration and reductive amination of ketones and aldehydes with HBpin by a bench stable Pd(II)-catalyst》.Formula: C7H7NO The author mentioned the following in the article:
A palladium(II) complex [(κ4-{1,2-C6H4(N:CHC6H4O2)2})Pd] (1) supported by a dianionic salen ligand [1,2-C6H4(NCH-C6H4O)2]2- (L) was synthesized and used as a mol. pre-catalyst in the hydroboration of aldehydes and ketones. The mol. structure of Pd(II) complex 1 was established by single-crystal x-ray diffraction anal. Complex 1 was tested as a competent pre-catalyst in the hydroboration of aldehydes and ketones with pinacolborane (HBpin) to produce corresponding boronate esters in excellent yields at ambient temperature under solvent-free conditions. Further, the complex 1 proved to be a competent catalyst in the reductive amination of aldehydes with HBpin and primary amines under mild and solvent-free conditions to afford a high yield (up to 97%) of corresponding secondary amines. Both protocols provided high conversion, superior selectivity and broad substrate scope, from electron-withdrawing to electron-donating and heterocyclic substitutions. A computational study based on d. functional theory (DFT) revealed a reaction mechanism for Pd-catalyzed hydroboration of carbonyl species in the presence of HBpin. The protocols also uncovered the dual role of HBpin in achieving the hydroboration reaction. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Formula: C7H7NO)
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Formula: C7H7NO