In 2022,Pothireddy, Mohanreddy; Bhukta, Swadhapriya; Babu, P. Vijaya; Thirupathi, Barla; Dandela, Rambabu published an article in Synthetic Communications. The title of the article was 《Synthetic method to access fluorinated 2-benzylpyridines by using Negishi coupling reaction》.Application In Synthesis of 2-Bromo-5-methylpyridine The author mentioned the following in the article:
The 2-benzylpyridines scaffolds I (R = 4-Me, 3-Cl, 2-trifluoromethyl, etc.) have been found in various drugs, bioactive natural products, and medicinally important compounds This manuscript comprises the synthesis of various fluorinated analogs of 2-benzylpyridine compounds I by using a Negishi coupling reaction as a key reaction. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-methylpyridine(cas: 3510-66-5Application In Synthesis of 2-Bromo-5-methylpyridine)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application In Synthesis of 2-Bromo-5-methylpyridine