Nakamura, Hugh; Yasui, Kosuke; Kanda, Yuzuru; Baran, Phil S. published the artcile< 11-Step Total Synthesis of Teleocidins B-1-B-4>, Category: pyridine-derivatives, the main research area is teleocidin B synthesis.
A unified and modular approach to the teleocidin B family of natural products is presented that proceeds in 11 steps and features an array of interesting strategies and methods. Indolactam V, the known biosynthetic precursor to this family, was accessed through electrochem. amination, Cu-mediated aziridine opening, and a remarkable base-induced macrolactamization. Guided by a desire to minimize concession steps, the tactical combination of C-H borylation and a Sigman-Heck transform enabled the convergent, stereocontrolled synthesis of the teleocidins.
Journal of the American Chemical Society published new progress about Amination (electrochem.). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Category: pyridine-derivatives.