Chinna Ayya, Swamy .P.; Varenikov, Andrii; de Ruiter, Graham published the artcile< Chiral Imidazo[1,5-a]pyridine-Oxazolines: A Versatile Family of NHC Ligands for the Highly Enantioselective Hydrosilylation of Ketones>, Recommanded Product: 1-(Pyridin-3-yl)ethanone, the main research area is chiral imidazopyridineoxazoline bidentate ligand preparation cyclometalation rhodium complex; rhodium imidazopyridineoxazoline bidentate carbene complex preparation catalyst hydrosilylation ketone; alc chiral enantioselective preparation.
Herein the authors report the synthesis and application of a versatile class of N-heterocyclic carbene ligands based on an imidazo[1,5-a]pyridine-3-ylidine backbone that is fused to a chiral oxazoline auxiliary. The key step in the synthesis of these ligands involves the installation of the oxazoline functionality via a microwave-assisted condensation of a cyano-azolium salt with a wide variety of 2-amino alcs. The resulting chiral bidentate NHC-oxazoline ligands form stable complexes with Rh(I) that are efficient catalysts for the enantioselective hydrosilylation of structurally diverse ketones. The corresponding secondary alcs. are isolated in good yields (typically >90%) with good to excellent enantioselectivities (80-95% ee). The reported hydrosilylation occurs at ambient temperatures (40°), with excellent functional group tolerability. Even ketones bearing heterocyclic substituents (e.g., pyridine or thiophene) or complex organic architectures are hydrosilylated efficiently, which is discussed further.
Organometallics published new progress about Alcohols, chiral Role: SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.