Conde, Nerea; SanMartin, Raul; Herrero, Maria Teresa; Dominguez, Esther published the artcile< Palladium NNC Pincer Complex as an Efficient Catalyst for the Cycloisomerization of Alkynoic Acids>, Product Details of C7H6BrNO2, the main research area is alkynoic acid cycloisomerization palladium NNC pincer complex catalyst.
A two-step (nucleophilic substitution/palladation by oxidative addition) sequence provides a high-yielding access to a non-sym. palladium NNC pincer complex. A number of terminal and internal alkynoic acids with different substitution patterns at the α- and β-positions are regio- and diastereoselectively cycloisomerized to the corresponding exocyclic enol lactones in the presence of exceedingly low amounts of the latter palladium complex, so that unprecedented turnover numbers and frequencies ranging from 1000,000 to 700,000 and from 41,667 to 9722 h-1, resp., are achieved. The optimized protocol, based on the use of a catalytic amount of triethylamine as base, allows an easy real-time monitoring of the reaction by NMR spectroscopy. Several pieces of evidence in favor of the direct participation of the above pincer complex as the catalyst of the reaction were gathered from kinetic and poisoning experiments
Advanced Synthesis & Catalysis published new progress about Carboxylic acids, alkynyl Role: RCT (Reactant), RACT (Reactant or Reagent). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Product Details of C7H6BrNO2.