Hussain, Afzal; AlAjmi, Mohamed Fahad; Rehman, Tabish Md.; Amir, Samira; Husain, Fohad Mabood; Alsalme, Ali; Siddiqui, Maqsood Ahmad; AlKhedhairy, Abdulaziz A.; Khan, Rais Ahmad published the artcile< Copper(II) complexes as potential anticancer and Nonsteroidal anti-inflammatory agents: In vitro and in vivo studies>, Electric Literature of 366-18-7, the main research area is copper complex anticancer nonsteroidal antiinflammatory agent breast cancer.
Copper-based compounds are promising entities for target-specific next-generation anticancer and NSAIDS therapeutics. In lieu of this, benzimidazole scaffold plays an important role, because of their wide variety of potential functionalizations and coordination modes. Herein, we report three copper complexes 1-3 with benzimidazole-derived scaffolds, a biocompatible mol., and secondary ligands viz, 1-10-phenanthroline and 2,2′-bipyridyl. All the copper complexes have been designed, synthesized and adequately characterized using various spectroscopic techniques. In-vitro, human serum albumin (HSA) binding was also carried out using fluorescence technique and in-silico mol. modeling studies, which exhibited significant binding affinities of the complexes with HSA. Furthermore, copper complexes 1-3 were tested for biol. studies, i.e., anticancer as well as NSAIDS. In vitro cytotoxicity results were carried out on cultured MCF-7 cell lines. To get the insight over the mechanism of action, GSH depletion and change in lipid peroxidation were tested and thus confirmed the role of ROS generation, responsible for the cytotoxicity of the complexes 1-3. Moreover, the copper complexes 1-3 were tested for potential to act as NSAIDS on albino rats and mice in animal studies in-vivo. Addnl., we also predicted the mechanism of action of the copper complexes 1-3 using mol. modeling studies with COX-2 inhibitor.
Scientific Reports published new progress about Analgesics. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Electric Literature of 366-18-7.