Chen, Tiffany Q.; Pedersen, P. Scott; Dow, Nathan W.; Fayad, Remi; Hauke, Cory E.; Rosko, Michael C.; Danilov, Evgeny O.; Blakemore, David C.; Dechert-Schmitt, Anne-Marie; Knauber, Thomas; Castellano, Felix N.; MacMillan, David W. C. published the artcile< Unified Approach to Decarboxylative Halogenation of (Hetero)aryl Carboxylic Acids>, Quality Control of 777931-67-6, the main research area is hetero aryl halide preparation photochem; aryl hetero carboxylic acid decarboxylative halogenation copper catalyst.
A general catalytic method for direct decarboxylative halogenation of (hetero)aryl carboxylic acids RC(O)OH (R = 4-sulfamoylphenyl, 5-methylpyridin-2-yl, isoquinolin-1-yl, etc.) via ligand-to-metal charge transfer was reported. This strategy accommodates an exceptionally broad scope of substrates. An aryl radical intermediate is leveraged toward divergent functionalization pathways: (1) atom transfer to access bromo- or iodo(hetero)arenes or (2) radical capture by copper and subsequent reductive elimination to generate chloro- or fluoro(hetero)arenes. The proposed ligand-to-metal charge transfer mechanism is supported through an array of spectroscopic studies.
Journal of the American Chemical Society published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 777931-67-6 belongs to class pyridine-derivatives, and the molecular formula is C6H5BrClNO, Quality Control of 777931-67-6.