Lu, Hongyan; Zhao, Qinfu; Wang, Xiudan; Mao, Yuling; Chen, Caishun; Gao, Yikun; Sun, Changshan; Wang, Siling published the artcile< Multi-stimuli responsive mesoporous silica-coated carbon nanoparticles for chemo-photothermal therapy of tumor>, Name: 1,2-Di(pyridin-2-yl)disulfane, the main research area is mesoporous silica carbon nanoparticle delivery chemophotothermal therapy cancer; Carbon dots; Chemo-photothermal synergistic therapy; Controlled release; Mesoporous silica-coated mesoporous carbon; Stimuli-response.
In this work, a traceable dual-porous mesoporous silica-coated mesoporous carbon nanocomposite with high drug loading capacity and high photothermal conversion efficiency (30.5%) was successfully prepared Based on the nanocomposite, a pH/redox/near IR multi-stimuli responsive drug delivery system was constructed to realize the accurate drug delivery, drug controlled release and chemo-photothermal synergistic antitumor therapy. MCN@Si was used as a vehicle to load doxorubicin with a high drug loading efficacy of 48.2% and a NIR absorbance agent for photothermal therapy and NIR thermal imaging. Carbon dots with proper size were covalently attached to the surface of MCN@Si via disulfide bonds to block the mesopores, preventing DOX premature release from DOX/MCN@Si-CDs. DOX was rapidly released at the condition of low pH and high GSH concentration due to the breakage of disulfide bonds and protonation of DOX. Moreover, the local hyperthermia generated by MCN@Si-CDs under NIR irradiation could not only directly kill cells, but also accelerate DOX release and enhance cells sensitivity and permeability. Two-dimensional cells and three-dimensional tumor spheroids assays illustrated that DOX/MCN@Si-CDs + NIR group exhibited thermochemotherapy synergistic treatment effect and combination index was 0.378. All the results demonstrated that DOX/MCN@Si-CDs is a traceable multi-stimuli responsive nanodelivery system and can achieve efficient chemo-photothermal synergistic antitumor therapy.
Colloids and Surfaces, B: Biointerfaces published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Name: 1,2-Di(pyridin-2-yl)disulfane.